My theory for how to get hight CTR in AdSense

I think there no such rule that not to make background color or to remove borders or to embed your ads inside your content, my theory is you should do these all together.
People are different kinds, some are interested to click ads because they know others just ignore ads if they look so.
The best thing is to put :
1 ad unit borderless and embedded inside content
1 ad unit with different background color than page
1 ad unit with borders and rounded corners for example

other thing is to distribute ads locations among pages that is to put one in header one in footer and one embedded for example (must not exceed 3 ad units), try not to put 2 ad units beside each other or that they appear on browser near without scrolling down.